Mirtazapine-fluoxetine
From Psychiatrienet
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Switch medication from mirtazapine to fluoxetine.[1] [2]
Stop mirtazapine - Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start fluoxetine- Day 1: simultaneously start fluoxetine in a normal dosage of 20 mg/day.
- Day 8: stop administration of mirtazapine and only continue administration of fluoxetine in a dosage of 20 mg/day.
More information- Pharmacokinetic interaction is not important because of low plasma levels.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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