Paliperidone ER-Lurasidone
From Psychiatrienet
* This switch is intended for paliperidone long acting (Xeplion®, 30 days)
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Switch medication from Paliperidone LA to Lurasidone.[1] [2]
Stop Paliperidone LA - Day 1: Last depot injection
Start Lurasidone- Week 1-3: approx. 25% of target dose
- Week 4-6: approx. 50% of target dose
- Week 7-9: approx. 75% of target dose
- Week 10: target dose
More information- More information on switching to lurasidon: see reference. [3]
— Paliperidone LA — Lurasidone
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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