Difference between revisions of "Agomelatine-fluvoxamine"

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Revision as of 15:11, 4 May 2009

Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from agomelatine to fluvoxamine.[1] [2]

Nietinrijdenbord.png Stop agomelatine
  • Gradually reduce dosage of agomelatine to a maximum of 25 mg/day.
  • When a dosage of 25 mg/day is reached , stop administration.
Eenrichtingbord.png Start fluvoxamine
  • A wash-out period of one day is necessary.
  • Start administration of fluvoxamine the next day in a normal dosage of 50 mg/day.
Infobord.png More information
  • Fluvoxamine stops the metabolism of agomelatine via CYP1A2 and CYP2C9.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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