Difference between revisions of "Amitriptyline-bupropion"

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{{stopAmitriptyline1}}
 
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* '''Day 7:''' start administration of bupropion in a dosage of 150 mg/day.
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* '''Day 8:''' start administration of bupropion in a dosage of 150 mg/day.
 
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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
 
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.

Latest revision as of 15:55, 28 October 2015

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from amitriptyline to bupropion.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
  • Day 1: reduce dosage of amitriptyline to 50 mg/day.
  • Day 8: reduce dosage of amitriptyline to 25 mg/day.
  • Day 15: stop administration of amitriptyline.
Eenrichtingbord.png Start bupropion
  • Day 8: start administration of bupropion in a dosage of 150 mg/day.
Infobord.png More information
  • Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
  • The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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