* '''Before day 01:''' gradually reduce dosage of amitriptyline to a maximum of 25-50 mg/day.

* '''Day 38:''' reduce dosage of stop amitriptyline to 10 mg/day.

Caution is necessary.* '''Day 18:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day.* '''Day 815:''' stop administration of amitriptyline and continue administration of mianserine. * If if necessary, increase dosage of mianserine. }}