* '''Day 1-7:''' a wash-out period start paroxetine the next day in low dosage of at least one week is necessary10 mg/day. * '''Day 8:''' start paroxetine with 20 mg/day.If necessary, gradually increase dosage| info = * By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. * Bupropion slows the metabolism of paroxetine by CYP2D6.}}