* '''Day 1-7:''' a wash-out period start paroxetine the next day in low dosage of at least one week is necessary10 mg/day. * '''Day 8:''' start paroxetine the next day in low If necessary, gradually increase dosage of 10 mg/day.| info = * By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. * Bupropion slows the metabolismof paroxetine by CYP2D6.}}