* A wash-out period is not necessary''' Day 1: ''' Start vortioxetine with a dosage of 5 mg/day.* Start administration ''' Day 8: ''' increase dosage of vortioxetine the next day in to a dosage of 10 mg/day.

* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.slows the metabolism of vortioxetine via CYP2D6