* '''Day 1:''' start administration of Start vortioxetine in with a normal dosage of 10 5 mg/day.* '''Day 8:''' if necessary, increase dosage of sertralinevortioxetine to a dosage of 10 mg/day.

* Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually.slows the metabolism of vortioxetine via CYP2D6