Chlorpromazine-Partial agonist

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Chlorpromazine
Type Antipsychotic
Group Phenothiazines
links
Medscape Chlorpromazine
PubChem 2726
PubMed Chlorpromazine
Kompas (Dutch) Chlorpromazine
Wikipedia Chlorpromazine
Partial agonists

Aripiprazole
Brexpiprazole
Cariprazine

Switch medication from Chlorpromazine to Partial agonist.
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.

Nietinrijdenbord.png Stop Chlorpromazine
  • Week 1: approx. 75% of initial dose
  • Week 2: approx. 50% of initial dose
  • Week 3: approx. 25% of initial dose
  • Week 4: approx. 12,5% of initial dose
  • Day 28: stop
Eenrichtingbord.png Start Partial agonist
  • Day 1-3: start 50% of target dose
  • Day 4-7: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
    Anticholinerg AP naar partieel3.jpg
Nietinrijdenbord.png — Chlorpromazine
Eenrichtingbord.png — Partial agonist


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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