Difference between revisions of "Citalopram-vortioxetine"

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| to = vortioxetine  
 
| to = vortioxetine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.  
+
* '''Day 1-8:''' Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.  
* '''Day 1:''' When a dosage of 20 mg/day is reached, stop administration.  
+
* '''Day 8:''' When a dosage of 20 mg/day is reached, stop administration.  
 
| start =  
 
| start =  
* A wash-out period is not necessary, but care is needed.
+
{{washout8-14}}
* '''Day 1:''' Start administration of vortioxetine in a dosage of 10 mg/day.
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* '''Day 15:''' Start administration of vortioxetine in a dosage of 10 mg/day.
 
| info =
 
| info =
 
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxetine.  
 
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxetine.  

Revision as of 13:48, 12 March 2015

Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from citalopram to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Day 1-8: Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
  • Day 8: When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start vortioxetine
  • Day 8-14: a wash-out period of 1 week is necessary.
  • Day 15: Start administration of vortioxetine in a dosage of 10 mg/day.
Infobord.png More information
  • Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxetine.
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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