Difference between revisions of "Clomipramine-citalopram"

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| to = citalopram  
 
| to = citalopram  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
+
{{stopClomipramine}}
* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.
 
* '''Day 3:''' reduce dosage of clomipramine to 10 mg/day.
 
* '''Day 8:''' stop administration of clomipramine.
 
 
| start =  
 
| start =  
 
* '''Day 1:''' simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
 
* '''Day 1:''' simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
+
* {{theroSS}}
 
* Citalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.
 
* Citalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.
{{review}}
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}}
}}
 

Revision as of 11:57, 4 November 2015

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from clomipramine to citalopram.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of clomipramine to 50 mg/day.
  • Day 4-7: reduce dosage of clomipramine to 25 mg/day.
  • Day 8: stop administration of clomipramine.
Eenrichtingbord.png Start citalopram
  • Day 1: simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
Infobord.png More information
  • Template:TheroSS
  • Citalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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