* '''Day 8-1415:''' a wash-out period of one week is necessary.* '''Day 1516:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).| info caveat = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{caveSS}} * Hypericum slows the metabolism of clomipramine via CYP3A4. }}