editor, reviewer
154
edits
Changes
no edit summary
{{Drugcombi
| base = risperidonearipiprazole
| add = carbamazepine
| info =
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone aripiprazole via induction of CYP450 3A4 and its pharmacologically active metabolite, 9p-hydroxyrisperidoneglycoprotein.* Risperidone Aripiprazole should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">{{Drugscominteract|risperidonearipiprazole-with-carbamazepine-497233-0-2019497-0|risperidonearipiprazole|carbamazepine}}</ref>
| cave =
* Pharmacologic response and plasma risperidone aripiprazole levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="drugscom" /> <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref>
}}