Difference between revisions of "Combining-Carbamazepine-Gabapentin"

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{{Drugcombi
 
{{Drugcombi
 
| base = carbamazepine
 
| base = carbamazepine
| add = gabapentine
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| add = gabapentin
| info =  
+
| info =  
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
 
* Gabapentine is eliminated unchanged by the kidney for 100%.
 
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
 
 
| start =  
 
| start =  
* Start gabapentine according to the general dosing advice.
+
* Start gabapentin according to the general dosing advice. {{CombiCaGa}}
 
| cave =  
 
| cave =  
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
+
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.<ref name="drugscom">{{Drugscominteract|carbamazepine-with-gabapentin-1147-0-497-0|carbamazepine|gabapentin}}</ref>   
{{Drugscominteract|carbamazepine-with-gabapentine|carbamazepine|gabapentine}}</ref>   
 
 
}}
 
}}

Latest revision as of 14:50, 23 April 2010

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin

Adding gabapentin to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Gabapentin is eliminated unchanged by the kidney for 100%.

 

Eenrichtingbord.png Start gabapentin
  • Start gabapentin according to the general dosing advice. Coadministration of carbamazepine with gabapentin appears to be safe, with no significant interactions. Dose adjustments and additional blood level monitoring are not necessary.[5]
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.[6]


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