Difference between revisions of "Combining-Carbamazepine-Olanzapine"

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* Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|9860152|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref>
 
* Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|9860152|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref>
 
* Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref><ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
 
* Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref><ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
| cave = <ref>{{drugscominteract|ativan-with-olanzapine-1488-899-1744-0|carbamazepine|olanzapine}}</ref>
+
| cave = <ref>{{drugscominteract|carbamazepine-with-zyprexa-497-0-1744-1113|carbamazepine|olanzapine}}</ref>
 
}}
 
}}

Revision as of 20:01, 4 March 2010

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Adding olanzapine to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
Eenrichtingbord.png Start olanzapine
  • Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. [6]
  • Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. [7][8]
Letopbord.png Cave

[9]


  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid <ref> tag; name "ftktox" defined multiple times with different content
  3. Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. 4.0 4.1 4.2 4.3 4.4 KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  5. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  6. Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43
  7. Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
  8. Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
  9. Interactions between carbamazepine and olanzapine on drugs.com
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