editor, reviewer
154
edits
Changes
no edit summary
{{Drugcombi
| base = Carbamazepinecarbamazepine| add = Olanzapinerisperidone
| info =
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
| start =
* Carbamazepine can reduce olanzapine serum concentrationCoadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, possible below therapeutic range9-hydroxyrisperidone. * Risperidone should be given at higher dosage to control psychotic symptoms. <refname="drugscom"> {{PubmedDrugscominteract|9860152risperidone-with-carbamazepine|risperidone|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref>* Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
| cave =
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref>
}}