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{{Drugcombi
| base = Carbamazepinecarbamazepine| add = Risperidonerisperidone
| info =
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Risperidone is principally metabolized by CYP2D6 to an active metabolite.* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.* Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">{{DRUGSCOMDrugscominteract|olanzapinerisperidone-with-carbamazepine|risperidone|carbamazepine}}</ref>
| cave =
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref>
}}