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Combining-Risperidone-Carbamazepine

34 bytes removed, 12:00, 8 June 2010
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| add = carbamazepine
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
{{Drugscominteract|risperidone-with-carbamazepine-497-0-2019-0|risperidone|carbamazepine}}</ref>
| cave =
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="drugscom" /> <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref>
}}
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