Difference between revisions of "Combining-Risperidone-Gabapentin"

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(Created page with '{{Drugcombi | base = risperidone | add = gabapentin | info = * Risperidone is principally metabolized by CYP2D6 to an active metabolite. * Gabapentine is eliminated unchanged b...')
 
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* Risperidone is principally metabolized by CYP2D6 to an active metabolite.  
 
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.  
 
* Gabapentine is eliminated unchanged by the kidney for 100%.
 
* Gabapentine is eliminated unchanged by the kidney for 100%.
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
+
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
 
| start =  
 
| start =  
 
* Start gabapentine according to the general dosing advice.
 
* Start gabapentine according to the general dosing advice.

Revision as of 00:06, 10 March 2010

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin

Adding gabapentin to risperidone.

Infobord.png General information
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Gabapentin is eliminated unchanged by the kidney for 100%.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite.
  • Gabapentine is eliminated unchanged by the kidney for 100%.
  • This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
Eenrichtingbord.png Start gabapentin
  • Start gabapentine according to the general dosing advice.
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [5]


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