326
edits
Changes
no edit summary
| add = carbamazepine
| info =
* Valproic acid A synergistic effect is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferasessuggested.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Valproic acid is an inhibitor Mood stabilizer Combinations: A Review of the enzymes CYP2C9, epoxide-hydroxylase Safety and UDPEfficacy. Am J Psychiatry 1998;155:12-glucuronosyltransferases. * 21}}</ref>*
| start =
* Valproate can increase carbamazepine-epoxide serum concentrations. Define valproate serum concentration before starting carbamazepine.* Start carbamazepine according to the general dosing advice. Check valproate and carbamazepine serum concentration (+ epoxide) after 2 weeks of therapy and adapt dose if necessary. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref>| cave = {{CombiCaVa}}
}}