editor, reviewer
1,499
edits
Changes
no edit summary
| add = topiramate
| info =
| start =
* Start topiramate according to general dosing advice. Pharmacologic response to the drugs should be monitored more closely following addition or withdrawal of one or the other drug. <ref name="drugscom">{{DRUGSCOMdrugscominteract|olanzapinetopiramate-with-valproic-acid-2216-0-2286-0|valproic acid|topiramate}}</ref>
| cave =
* Topiramate has been shown to produce a small but significant increase in valproate clearance, reducing plasma levels.
* Topiramate plasma levels are increased by about 15% by valproate, which could be important if valproare valproic acid is withdrawn. <ref name=”bazire”"bazire"> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
}}