Difference between revisions of "Dosulepine-citalopram"

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* '''Day 7:''' stop dosulepine
 
* '''Day 7:''' stop dosulepine
 
| start =  
 
| start =  
* '''Day 8:''' start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
+
* '''Day 8:''' start administration of citalopram in a normal dosage of 20 mg/day.
 
| info =  
 
| info =  
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes dosulepine.  }}
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* Citalopram is a weak inhibitor of CYP2D6, which metabolizes dosulepine.   
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}}

Revision as of 22:54, 4 March 2010

dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from dosulepine to citalopram.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
  • Day 1: reduce dosage of dosulepine to 50 mg/day.
  • Day 3: reduce dosage of dosulepine to 25 mg/day.
  • Day 7: stop dosulepine
Eenrichtingbord.png Start citalopram
  • Day 8: start administration of citalopram in a normal dosage of 20 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • Citalopram is a weak inhibitor of CYP2D6, which metabolizes dosulepine.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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