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Dosulepine-fluoxetine

125 bytes removed, 8 March
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{{Drugswitch
| from = dosulepine | to = fluoxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day.* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day.* '''Day 7:''' stop dosulepine{{TCAdecrease25p3d}}
| start =
* '''Day 8:6 and after''' : At approximately 50-25% of the original TCA dosering start administration fluoxetine at 100% of fluoxetine in a normal the target dose.* ''' After 3 weeks:''' If necessary, gradually increase dosage of 20 mg/dayfluoxetine
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose fluoxetine = 20 mg* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6, (strong) which metabolizes metabolize dosulepine. }}