Difference between revisions of "Dosulepine-fluoxetine"

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine.  }}
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* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine.  
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Revision as of 16:51, 28 October 2015

dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from dosulepine to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
  • Day 1: reduce dosage of dosulepine to 50 mg/day.
  • Day 3: reduce dosage of dosulepine to 25 mg/day.
  • Day 7: stop dosulepine
Eenrichtingbord.png Start fluoxetine
  • Day 8: start administration of fluoxetine in a normal dosage of 20 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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