| to = sertraline
| stop =
* '''Before day 1:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day.* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day.* '''Day 7:''' stop administration of dosulepine.{{TCAdecrease25p3d}}| start = * '''Day 8:''' start administration of sertraline in a normal dosage of 50 mg/day.* '''Day 22:''' if necessary increase dosage of sertraline to 100 mg/day.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose sertraline = 50 mg* Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine. {{review}}
}}