Dosulepine-sertraline

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dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from dosulepine to sertraline.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
  • Day 1: reduce dosage of dosulepine to 50 mg/day.
  • Day 3: reduce dosage of dosulepine to 25 mg/day.
  • Day 7: stop administration of dosulepine.
Eenrichtingbord.png Start sertraline
  • Day 8: start administration of sertraline in a normal dosage of 50 mg/day.
  • Day 22: if necessary increase dosage of sertraline to 100 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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