* '''Before day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day. * '''Day 1:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day.* '''Day 8:''' stop administration of duloxetine.{{TCAdecrease25p3d}}| start = {{StartAgomelatine}}* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}