| to = amitriptyline
| stop =
* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day. * '''Day 1:''' reduce dosage of duloxetine to a maximum of 30 mg/day. * '''Day 8:''' stop administration of duloxetine.{{TCAdecrease25p3d}}
| start =
A wash-out period of one week is necessary.* '''Day 8-14:''' wash-out period. * '''Day 15:''' start administration of amitriptyline in a low dosage of 25 mg/day. {{TCAincrease25p3d}}| info = * Start low, go slow for amitriptyline!{{TCAplasmalevelmonitoring}}* Duloxetine is a moderate inhibitor of CYP2D6, which metabolizes amitriptyline}}