| to = nortriptyline
| stop =
* '''Before day 0:''' gradually reduce dosage of bupropion to a maximum of 60 mg/day. * '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day.{{TCAdecrease25p3d}}
| start =
No wash-out period is needed. * '''Day 1:''' simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.* '''Day 8:''' stop administration of duloxetine and increase the dosage of nortriptyline to 50 mg/day.{{TCAincrease25p3d}}| info = * Duloxetine slows the metabolism of nortriptyline by CYP2D6.{{TCAplasmalevelmonitoring}}* Caution is necessary at the start of administration of nortriptyline. }}