Difference between revisions of "Duloxetine-paroxetine"

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| to = paroxetine  
 
| to = paroxetine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day.
+
{{stopDuloxetine}}
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
 
* '''Day 8:''' stop duloxetine.
 
 
| start =  
 
| start =  
* '''Day 8:''' start paroxetine the next day in a normal dosage of 20 mg/day.
+
* '''Day 9:''' start paroxetine in a normal dosage of 20 mg/day.
 
| info =
 
| info =
 
* Paroxetine and duloxetine slow each others metabolism by CYP2D6-inhibition.
 
* Paroxetine and duloxetine slow each others metabolism by CYP2D6-inhibition.
 
* {{theorSS}}
 
* {{theorSS}}
{{review}}
 
 
}}
 
}}

Latest revision as of 12:21, 4 November 2015

Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from duloxetine to paroxetine.[1] [2]

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start paroxetine
  • Day 9: start paroxetine in a normal dosage of 20 mg/day.
Infobord.png More information
  • Paroxetine and duloxetine slow each others metabolism by CYP2D6-inhibition.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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