Fluoxetine-doxepine

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{{Drugswitch | from = fluoxetine | to = doxepin | stop =

  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.

| start = Caution is necessary for at least four weeks.

  • Day 2: start administration of doxepin in a low dosage of 25 mg/day.
  • Day 15: increase dosage of doxepin to 50 mg/day.
  • Day 29: increase dosage of doxepin to 75 mg/day.

|info =

  • Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Start low, go slow for doxepin.