Difference between revisions of "Fluoxetine-tranylcypromine"

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* '''Day 36:''' start tranylcypromine the next day in a low dosage of 20 mg/day for one week.
 
* '''Day 36:''' start tranylcypromine the next day in a low dosage of 20 mg/day for one week.
 
* '''Day 43:''' after this week the dosage of tranylcypromine can be increased if necessary.
 
* '''Day 43:''' after this week the dosage of tranylcypromine can be increased if necessary.
| info =   
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| caveat =   
* A switch from fluoxetine to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case.
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{{caveSS}}
* Occurrence of serotonin syndrome is reported when a wash-out period (of five weeks) is not considered.}}
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}}

Revision as of 08:48, 3 August 2009

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from fluoxetine to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop fluoxetine
  • Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start tranylcypromine

Caution is necessary.

  • Day 1-35: a wash-out period of five weeks is necessary.
  • Day 36: start tranylcypromine the next day in a low dosage of 20 mg/day for one week.
  • Day 43: after this week the dosage of tranylcypromine can be increased if necessary.
Letopbord.png Cave


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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