Fluoxetine-vortioxetine

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{{Drugswitch | from = fluoxetine | to = vortioxetine | stop =

  • Before day 1: reduce dosage of fluoxetine to 20 mg/day, when this dosage is > 20 mg/day.
  • Day 1: stop administration

| start =

  • Day 1-21: A wash-out period is needed.
  • Day 22: Start vortioxetine in a dosage of 10 mg/day.
  • After day 28 : If necessary, increase gradually the dosage of vortioxetine.

| info =

  • Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.
  • {{theorSS}

}}