Switch medication from fluoxetine to vortioxetine.
- Before day 1: reduce dosage of fluoxetine to 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: stop administration
- Day 1-21: A wash-out period is needed.
- Day 22: Start vortioxetine in a dosage of 10 mg/day.
- After day 28 : If necessary, increase gradually the dosage of vortioxetine.
- Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
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