| to = agomelatine
| stop =
* ''' Day 1:''' Stop hypericum.* The administration of hypericum can be stopped abruptly.{{Stophyp}}| start = {{StartAgomelatine}}* ''' Day 2: ''' Start administration of agomelatinein a dosage of 25 mg/day.* If necessary, increase dosage of agomelatine to 50 mg/day.
| info =
* Hypericum induces CYP1A2, which metabolizes agomelatine {{nointeractionsHypericumInfo}}
}}