* Administration of hypericum can be stopped abruptly.{{Stophyp}}| start = * '''Day 1-7:''' a wash-out period of one week is necessary.{{TCAincrease25p3d}}* '''Day 8:''' start administration of amitriptyline in a dosage of 25 mg/day.* If necessary, increase dosage of agomelatine to 50 mg/day.* Start low, go slow.| info = {{TCAplasmalevelmonitoring}}* Hypericum slows the metabolism The ratio of amitriptyline via CYP3A4/nortriptyline could change because of CPY2C19 induction. This effect may persist up Sum plasmalevels are not likely to two weeks after stopping hypericumchange because CYP2D6 is barely affected.{{caveSS}}{{HypericumInfo}}}}