| to = amitriptyline
| stop =
* '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum.{{Stophyp}}
| start =
* '''Day 15-30:''' a wash-out period of at least two weeks is necessary. {{TCAincrease25p3d}} * '''Day 31:''' start amitriptyline 25 mg/day.| info = {{TCAplasmalevelmonitoring}}* Occurrence The ratio of the serotonin syndrome amitriptyline/nortriptyline could change because of CPY2C19 induction. Sum plasmalevels are not likely to change because CYP2D6 is possible without wash-out periodbarely affected.* Hypericum induces enzymes of the CYP P-450 type and P-gp.{{caveSS}}{{HypericumInfo}}* Hypericum probably has MAO-inhibiting properties.}}