* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-722:''' a wash-out period of at least one week is necessary..<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|imipramine}}</ref> * '''Day 823:''' start administration of imipramine in a dosage of 25-50 mg/day.* If necessary, increase dosage Increase the dose with about 25% of imipramine to 50-75 mg/daythe target dose every 3 days.* Start low, go slow.| info = * Hypericum slows the metabolism of imipramine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.{{HypericumInfo}}{{caveSS}}}}