| to = mirtazapine venlafaxine

* Administration '''Day 1-14:''' Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-722:''' a wash-out period of at least one week is necessary.* <ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern'Day 8herbal antidepressant:''' start administration pharmacokinetics of venlafaxine in a dosage of 37,active ingredients. Clin Pharmacokinet. 2006;45(5 mg):449-68.}}</dayref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC.Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|venlafaxine}}</ref> * '''Day 1523:''' increase dosage {{startVenla}} Increase the dose with about 25% of venlafaxine to 75 mg/daythe target dose every 3 days.* If necessary, increase dosage of venlafaxine further. 

* Occurence of the serotonin syndrome is theoretically possible.{{HypericumInfo}}{{caveSS}}* Hypericum slows the metabolism of venlafaxine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}