* '''Day 15-3022:''' a wash-out period of at least two weeks one week is necessary. * <ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern'Day 31herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):''' start venlafaxine 37449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ,5 mg or 75 mg Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(slow release4):405-8.}}</day.ref><ref name="informatorium">{{KNMP| caveat =venlafaxine}}</ref> * Occurrence '''Day 23:''' {{startVenla}} Increase the dose with about 25% of the serotonin syndrome is possible without wash-out periodtarget dose every 3 days.