Difference between revisions of "Imipramine-tranylcypromine"

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* Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary<ref [DrugBank http://www.drugbank.ca/drugs/DB01151]</references>
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* Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary<ref>DrugBank[http://www.drugbank.ca/drugs/DB01151]</ref>
 
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Revision as of 13:45, 4 October 2016

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from imipramine to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Decrease with about 25% of original dose every 3 days
  • Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary[3]
Eenrichtingbord.png Start tranylcypromine
  • Start tranylcypromine in a low dosage of 20 mg/day for one week.
  • After this week the dosage of tranylcypromine can be increased.
Letopbord.png Cave


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. DrugBank[1]
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