Switch medication from imipramine to tranylcypromine.
- Decrease with about 25% of original dose every 3 days
- Because of the half life of desipramine of up to 3 days a washout period of 2 weeks is necessary<ref DrugBank</references>
- Start tranylcypromine in a low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased.
- Occurrence of the serotonin syndrome is possible without wash-out period.
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