| to = trazodone
| stop =
* '''Before day 0:''' gradually reduce dosage of imipramine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of imipramine to 25 mg/day.* '''Day 8:''' stop administration of imipramine.{{TCAdecrease25p3d}}| start = No wash-out period is needed. * '''Day 4:''' simultaneously start administration of trazodone in a dosage of 150 mg/day.* '''Day 8:''' continue only administration of trazodone. * {{upTrazoStartAntidepressant}}If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.| info = * Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.Safe target dose trazodone = 150 mg}}