Difference between revisions of "Maprotiline-paroxetine"

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| to = paroxetine
 
| to = paroxetine
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
+
{{stopMaprotiline}}
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
 
* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day.
 
* '''Day 14:''' stop dosage of maprotiline.
 
 
| start =  
 
| start =  
 
* '''Day 7:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
 
* '''Day 7:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
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| info =  
 
| info =  
 
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.  
 
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.  
{{review}}
 
 
}}
 
}}

Revision as of 13:53, 2 November 2015

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from maprotiline to paroxetine.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Before day 1: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
  • Day 1: reduce dosage of maprotiline to 50 mg/day.
  • Day 7: reduce dosage of maprotiline to 25 mg/day.
  • Day 14: stop dosage of maprotiline.
Eenrichtingbord.png Start paroxetine
  • Day 7: simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
  • Day 14: stop administration of maprotiline and continue administration of paroxetine.
Infobord.png More information
  • Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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