Difference between revisions of "Maprotiline-tranylcypromine"

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| to = tranylcypromine  
 
| to = tranylcypromine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
+
{{stopMaprotiline}}
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
 
* '''Day 7:''' reduce dosage of maprotiline to 25 mg/day.
 
* '''Day 14:''' stop dosage of maprotiline.
 
 
| start =  
 
| start =  
* '''Day 14-28:''' a wash-out period of two weeks is necessary.
+
* '''Day 15-29:''' a wash-out period of two weeks is necessary.
* '''Day 29:''' start administration of tranylcypromine in a low dosage of 20 mg/day for one week.
+
* '''Day 30:''' start administration of tranylcypromine in a low dosage of 20 mg/day for one week.
* '''Day 36:''' after this week the dosage of tranylcypromine can be increased if necessary.
+
* '''Day 37:''' after this week the dosage of tranylcypromine can be increased if necessary.
|info=
 
{{review}}
 
  
 
}}
 
}}

Revision as of 15:23, 28 October 2015

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from maprotiline to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Before day 1: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
  • Day 1: reduce dosage of maprotiline to 50 mg/day.
  • Day 7: reduce dosage of maprotiline to 25 mg/day.
  • Day 14: stop dosage of maprotiline.
Eenrichtingbord.png Start tranylcypromine
  • Day 15-29: a wash-out period of two weeks is necessary.
  • Day 30: start administration of tranylcypromine in a low dosage of 20 mg/day for one week.
  • Day 37: after this week the dosage of tranylcypromine can be increased if necessary.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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