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* '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
* '''Day 8:''' stop administration of mianserine.
| start =
* '''Day 1:''' simultaneously start citalopram/escitalopram in a normal dosage of 20 mg/day, respectively 10 mg/day.* '''Day 8:''' stop administration of mianserine and only continue administration of citalopram/escitalopram. * If necessary, increase the dosage of citalopram/escitalopram.
| info =
* Caution with this switch Citalopram is necessarya very weak inhibitor of CYP2D6, because citalopram/escitalopram slows the metabolism of which metabolizes mianserine via CYP2D6.}}