Switch medication from mianserine to paroxetine.
- Day 0: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
- Day 1: simultaneously start paroxetine in a normal dosage of 20 mg/day.
- Day 8: stop administration of mianserine and only continue administration of paroxetine.
- If necessary, increase the dosage of paroxetine .
- Caution with this switch is necessary, because paroxetine slows the metabolism of mianserine via CYP2D6.
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