| to = agomelatine
| stop =
* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day. * '''Day 1:''' reduce dosage of mirtazapine to 15 mg/day.* '''Day 8:''' stop administration of mirtazapine.{{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. <ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102startAgomelatine}}</ref>
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