Moclobemide-amitriptyline
From Psychiatrienet
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Switch medication from moclobemide to amitriptyline.[1] [2]
Stop moclobemide - Decrease with about 25% of original dose every 3 days
- Stop and wait for about 24 hour as a washout period
Start amitriptyline- Start with the initial dose
More information- No wash-out period is needed.
- Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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